XBB.1.5 just EXPLODED in new cases now becoming the DOMINANT variant in the USA with close to 75% of new cases in the Northeast and 41% of new cases across the country. This has all happened over a matter of a few weeks!
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
XBB.1.5 is closely related to the recombinant Omicron variant XBB. It has additional mutations including the F486P mutation that has been shown to grant additional immune evasion and high binding to human cells.
https://www.cell.com/cell/pdf/S0092-8674(22)01531-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015318%3Fshowall%3Dtrue
It seems to have a similar degree of immune evasion with both vaccinated and previously infected individuals as compared to XBB. Although it does also seem to bind to human cell receptors with a higher affinity.
https://twitter.com/yunlong_cao/status/1607915571001307137/photo/1
https://erictopol.substack.com/p/a-new-variant-alert
Home antigen testing seems to mostly be adequate (as adequate as with previous variants at least - video linked below on this). Although there is an FDA warning on a home saliva test that no longer seems to be accurate for XBB.
https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests#omicron
The bivalent BA.5 vaccine booster has the highest degree of protection against XBB and most likely XBB.1.5 compared with previous monovalent boosters, although still lowest for XBB as compared to other previous Omicron variants.
https://www.nejm.org/doi/full/10.1056/NEJMc2214293
Paxlovid most likely remains affective in treating XBB.1.5 given it's effectiveness against XBB and the lack of additional mutations in the protease of XBB.1.5. No available monoclonal antibodies seem to be effective.
https://www.nejm.org/doi/full/10.1056/NEJMc2214302
There doesn't seem to be anything to suggest it causes more severe disease. Interestingly though, the hospitalizations rate for the elderly in the Northeast does seem to be rising to a disproportionate degree suggesting a possible connection to XBB.1.5.
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
***Join our Patreon page for early access, exclusive content, and behind the scenes access!***
www.patreon.com/WBDR
Omicron Variants BQ and XBB - Immunity After Vaccination, Bivalent Booster, Previous Infection
https://youtu.be/aK2q_9M_o8E
Treatments For The Newest Omicron Variants (BQ.1.1 and XBB) - Paxlovid, Lagevrio, Veklury, And More
https://www.youtube.com/watch?v=sYEK44v9_Sw&t=97s
Omicron Variant Termed Nightmare Variant - XBB (XBB.1, XBB.2, XBB.3) Reinfection, Severity, Immunity
https://www.youtube.com/watch?v=xMxtqO600zc
________________________________________________________________________
Playlist on me having Omicron!
https://youtube.com/playlist?list=PLf5bMa9_tvRiDimGzqn0Z-C_BdNGeVsga
Playlist on COVID-19 Variants!
https://youtube.com/playlist?list=PLf5bMa9_tvRhS8JeQPc3x-lexqvlN2t3Q
Playlist with all videos on Long COVID:
https://youtube.com/playlist?list=PLf5bMa9_tvRim6Dw4dcG4qVcssxjRgwPp
_______________________________________________________________________
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PayPal:
https://www.paypal.com/donate?hosted_button_id=UQN2JGSYSQJEG
Buy Us A Coffee:
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YouTube Membership tab:
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We love to get involved in the #FOAMed world through Twitter as well. Come check us out, we would love to hear from you! @WhiteBoardDoct1
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________________________________________________________________________
DISCLAIMER
THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
#xbb.1.5 #xbb #omicronvariants #covid19news #medicaleducation
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
XBB.1.5 is closely related to the recombinant Omicron variant XBB. It has additional mutations including the F486P mutation that has been shown to grant additional immune evasion and high binding to human cells.
https://www.cell.com/cell/pdf/S0092-8674(22)01531-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015318%3Fshowall%3Dtrue
It seems to have a similar degree of immune evasion with both vaccinated and previously infected individuals as compared to XBB. Although it does also seem to bind to human cell receptors with a higher affinity.
https://twitter.com/yunlong_cao/status/1607915571001307137/photo/1
https://erictopol.substack.com/p/a-new-variant-alert
Home antigen testing seems to mostly be adequate (as adequate as with previous variants at least - video linked below on this). Although there is an FDA warning on a home saliva test that no longer seems to be accurate for XBB.
https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests#omicron
The bivalent BA.5 vaccine booster has the highest degree of protection against XBB and most likely XBB.1.5 compared with previous monovalent boosters, although still lowest for XBB as compared to other previous Omicron variants.
https://www.nejm.org/doi/full/10.1056/NEJMc2214293
Paxlovid most likely remains affective in treating XBB.1.5 given it's effectiveness against XBB and the lack of additional mutations in the protease of XBB.1.5. No available monoclonal antibodies seem to be effective.
https://www.nejm.org/doi/full/10.1056/NEJMc2214302
There doesn't seem to be anything to suggest it causes more severe disease. Interestingly though, the hospitalizations rate for the elderly in the Northeast does seem to be rising to a disproportionate degree suggesting a possible connection to XBB.1.5.
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
***Join our Patreon page for early access, exclusive content, and behind the scenes access!***
www.patreon.com/WBDR
Omicron Variants BQ and XBB - Immunity After Vaccination, Bivalent Booster, Previous Infection
https://youtu.be/aK2q_9M_o8E
Treatments For The Newest Omicron Variants (BQ.1.1 and XBB) - Paxlovid, Lagevrio, Veklury, And More
https://www.youtube.com/watch?v=sYEK44v9_Sw&t=97s
Omicron Variant Termed Nightmare Variant - XBB (XBB.1, XBB.2, XBB.3) Reinfection, Severity, Immunity
https://www.youtube.com/watch?v=xMxtqO600zc
________________________________________________________________________
Playlist on me having Omicron!
https://youtube.com/playlist?list=PLf5bMa9_tvRiDimGzqn0Z-C_BdNGeVsga
Playlist on COVID-19 Variants!
https://youtube.com/playlist?list=PLf5bMa9_tvRhS8JeQPc3x-lexqvlN2t3Q
Playlist with all videos on Long COVID:
https://youtube.com/playlist?list=PLf5bMa9_tvRim6Dw4dcG4qVcssxjRgwPp
_______________________________________________________________________
If you enjoy the content and feel inclined, here are some ways in which you can support us! Funds will go towards purchasing better equipment/software, dedicating more time to the channel, and continuing to strive towards taking this channel to the next level!
PayPal:
https://www.paypal.com/donate?hosted_button_id=UQN2JGSYSQJEG
Buy Us A Coffee:
A cool site where you can donate a few dollars to a Creator of your choosing as a tip!
https://www.buymeacoffee.com/WBDR
YouTube Membership tab:
It has a “Join” button at the top right corner of our Channel’s home page. We appreciate you!
We love to get involved in the #FOAMed world through Twitter as well. Come check us out, we would love to hear from you! @WhiteBoardDoct1
https://twitter.com/WhiteBoardDoct1
________________________________________________________________________
DISCLAIMER
THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
#xbb.1.5 #xbb #omicronvariants #covid19news #medicaleducation
